MEDICINE
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High blood pressure is one of the main cardiovascular risk factors (1). According to data from the PURE study, the prevalence of hypertension defined as blood pressure figures above 140/90 mmHg is 50.8% in Argentina, 52.6% in Brazil, 46.7% in Chile and 37.5% in Colombia, with only 18.3% of patients being controlled. The reduction of 10/5 mmHg in SBP / DBP reduces the incidence of stroke by 36%, heart failure by 38%, coronary events by 20%, and cardiovascular mortality by 16% (2). About 30% of hypertensive patients achieve blood pressure goals with monotherapy, about 70% require combination of two or more antihypertensive drugs, and about 25% of patients may require 3 or more antihypertensive drugs for their control (3) . Combined fixed dose therapies are currently recommended to improve adherence to treatment. Fixed-dose combinations of two antihypertensives are recommended as initial therapy in patients with hypertension with diastolic blood pressure above 100 mmHg (1).


  1. James PA, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014 Feb 5;311(5):507-20.
  2. López-Jaramillo P, Molina de Salazar DI, Coca A, Zanchetti A. Manual Práctico LASH de Diagnóstico y Manejo de la Hipertensión Arterial en Latinoamérica [Internet]. España: Caduceo Multimedia SL; 2015 (actualizado a 20 de marzo 2015); consultado 31 julio 2017.
  3. Gradman AH, Parisé H, Lefebvre P, Falvey H, Lafeuille MH, Duh MS. Initial combination therapy reduces the risk of cardiovascular events in hypertensive patients: a matched cohort study. Hypertension. 2013 Feb;61(2):309-18.

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